Glice Caution For Usage

Instruction for use and handling: Glyceryl trinitrate solution for injection for infusion need not be diluted before use but can be diluted by 1:10 up to 1:40 with 5% glucose solution, 5% glucose solution and 0.9% sodium chloride solution, or with 0.9% sodium chloride solution.
The solution, whether or not diluted, should be infused slowly and not given by bolus injection. To ensure a constant infusion rate of glyceryl trinitrate it is recommended that glyceryl trinitrate be administered by means of a syringe pump or polyethylene infusion bag with a counter, or with a glass or rigid polyethylene syringe and polyethylene tubing.
Incompatibilities: Glyceryl trinitrate is incompatible with polyvinylchloride (PVC) and severe losses of glyceryl trinitrate (up to 50%) may occur if this material is used, resulting in a reduction of delivered dose and efficacy. Contact with polyvinylchloride bags should be avoided. Polyurethane (PU) also induces a loss of the active ingredient.
Glyceryl trinitrate is compatible with glass infusion set and with rigid infusion packs made of polyethylene. Glyceryl trinitrate may also be infused slowly using a syringe pump with a glass or plastic syringe.