Forlax Mechanism of Action

Pharmacotherapeutic class: Osmotically acting laxatives. ATC code: A06AD15 (A: digestive system and metabolism).
Pharmacology: Pharmacodynamics: High molecular weight (4000) macrogols are long linear polymers on which water molecules are retained by hydrogen bonds. Following oral administration, they increase the volume of the intestinal fluids.
The volume of non-absorbed intestinal fluid is responsible for the laxative properties of the solution.
Pharmacokinetics: The pharmacokinetic data confirm that macrogol 4000 undergoes neither gastrointestinal resorption nor biotransformation following oral ingestion.
Toxicology: Preclinical Safety Data: 10 g: Toxicological studies in different species of animals did not reveal any signs of systemic or local gastrointestinal toxicity of macrogol 4000. Macrogol 4000 had no teratogenic or mutagenic effect. Potential drug interactions studies performed in rats on some NSAIDs, anticoagulants, gastric antisecretory agents, or on a hypoglycaemic sulfamide showed that FORLAX did not interfere with gastrointestinal absorption of these compounds. No carcinogenicity studies have been performed.