Entresto Description

Entresto 50 mg film-coated tablets: Each film-coated tablet contains 24.3 mg sacubitril and 25.7 mg valsartan (as sacubitril valsartan sodium salt complex).
Entresto 100 mg film-coated tablets: Each film-coated tablet contains 48.6 mg sacubitril and 51.4 mg valsartan (as sacubitril valsartan sodium salt complex).
Entresto 200 mg film-coated tablets: Each film-coated tablet contains 97.2 mg sacubitril and 102.8 mg valsartan (as sacubitril valsartan sodium salt complex).
Entresto contains a salt complex of the anionic forms of sacubitril and valsartan, sodium cations, and water molecules in the molar ratio of 1:1:3:2:5 respectively. Following oral administration, Entresto dissociates into sacubitril (which is further metabolized to LBQ657 [sacubitrilat]) and valsartan.
Excipients/Inactive Ingredients: Tablet core: Microcrystalline cellulose, Low-substituted hydroxypropylcellulose, Crospovidone, Magnesium stearate, Talc, Silica colloidal dioxide.
Film coat: Entresto 50 mg film-coated tablets: Hypromellose, Titanium dioxide (E171), Macrogol (4000), Talc, Iron oxide red (E172), Iron oxide black (E172).
Entresto 100 mg film-coated tablets: Hypromellose, Titanium dioxide (E171), Macrogol (4000), Talc, Iron oxide red (E172), Iron oxide yellow (E172).
Entresto 200 mg film-coated tablets: Hypromellose, Titanium dioxide (E171), Macrogol (4000), Talc, Iron oxide red (E172), Iron oxide black (E172).