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Hypersensitivity to the active substance or to any of the excipients.
Tumors of the ovary, breast, uterus, pituitary or hypothalamus.
Abnormal (not menstrual) vaginal bleeding without a known/diagnosed cause.
Primary ovarian failure.
Ovarian cysts or enlarged ovaries.
Fibroid Tumors of the uterus incompatible with pregnancy.
Malformations of the reproductive organs incompatible with pregnancy.
Pregnancy (see Use in Pregnancy & Lactation).
Risk factors of OHSS: A history of Ovarian Hyperstimulation Syndrome (OHSS); A previous COS cycle that resulted in more than 30 follicles ≥ 11 mm measured by ultrasound examination; A basal antral follicle count > 20; Polycystic ovarian syndrome (PCOS).
