Potential interactions between Elidel 1% cream and other drugs have not been systematically evaluated. Based on its minimal extent of absorption, interactions of Elidel 1% cream with systemically administered drugs are unlikely to occur (see Pharmacology: PHARMACOKINETICS under Actions).
A study that included 79 infants treated for up to 2 years showed that treatment with Elidel 1% Cream did not interfere with the protective immune response to childhood vaccinations.
Application of Elidel 1% cream to vaccination sites, as long as local reactions persist, was not studied and is therefore not recommended.