Dicloran Mechanism of Action

Pharmacology: Pharmacodynamics: Diclofenac sodium inhibits the activity of the enzyme cyclo-oxygenase, resulting in decreased formation of precursors of prostaglandin and thromboxanes from arachidonic acid.
Antirheumatic action: It acts via analgesic and anti-inflammatory mechanisms.
Analgesic action: Diclofenac block pain impulse generation via a peripheral action that involve reduction of the activity of prostaglandin, and possibly by inhibiting other substances responsible for sensitization of pain receptors to various stimulants.
Anti-inflammatory action: The exact mechanism of action of diclofenac have not been determined. Diclofenac acts by reducing prostaglandin activity in the inflamed tissues.
Diclofenac probably acts also by inhibiting leukocyte migration, inhibition of lysosomal enzyme.
Pharmacokinetics: The onset of action for diclofenac tablet is 30 minutes and duration of action is up to 8 hrs.
Synovial fluid concentrations.
Diclofenac enters the synovial fluid and that, several hrs. after administration of single dose, synovial fluid concentrations equal or exceed the simultaneously measured plasma concentrations. Diclofenac achieves maximum synovial concentrations of 0.28 microgram/mL after three hours (steady state - 50mg three times a day). The synovial fluid half-life is up to 6 hrs.