Dicloran Drug Interactions

Lithium: Dicloran may increase plasma concentrations and decrease elimination of lithium.
Cardiac glycosides: NSAIDs may exacerbate cardiac failure, reduce GFR and increase plasma glycoside levels.
Anticoagulants: NSAIDs may enhance the effects of anti-coagulants, such as warfarin.
Antidiabetic agents: Clinical studies have shown that Dicloran can be given together with oral hypoglycaemic agents without influencing their clinical effect. However there have been isolated reports of hyperglycaemic and hypoglycaemic effects, which have required adjustments to the dosage of hypoglycaemic agents.
Ciclosporin: Ciclosporin nephrotoxicity may be increased by the effect of NSAIDs on renal prostaglandins.
Mifepristone: NSAIDs should not be used for 8-12 days after mifepristone administration as NSAIDs can reduce the effect of mifepristone.
Methotrexate: Caution should not be exercised if NSAIDs and methotrexate are administered within 24 hours of each other, since NSAIDs may increase methotrexate plasma levels with decreased elimination, resulting in increased toxicity.
Quinolone antibiotics: Animal data indicate that NSAIDs can increase the risk of convulsions associated with quinolone antibiotics.
Patients taking NSAIDs and quinolones may have an increased risk of developing convulsions.
Other analgesics: Concomitant therapy with other systemic NSAIDs (including aspirin) may increase the frequency of side effects.
Corticosteroids: Corticosteroids can increase the risk of gastrointestinal bleeding.
Diuretics: Various NSAIDs are liable to inhibit the activity of diuretics. Diuretics can increase the risk of nephrotoxicity of NSAIDs. Concomitant treatment with potassium sparing diuretics may be associated with increased serum potassium levels, hence serum potassium should be monitored.
Anti-hypertensives: Reduced anti-hypertensive effect.
Tacrolimus: Possible increased risk of nephrotoxicity when NSAIDs are given with tacrolimus.