Cymevene Caution For Usage

Special Instructions for Use, Handling and Disposal: Caution should be exercised in the handling of Cymevene.
Since Cymevene is considered a potential teratogen and carcinogen in humans, caution should be observed in its handling (see Precautions). Avoid inhalation or direct contact of the powder contained in the vials or direct contact of the reconstituted solution with the skin or mucous membranes. Cymevene solutions are alkaline (pH ~11). If such contact occurs, wash thoroughly with soap and water, rinse eyes thoroughly with plain water.
Wearing disposable gloves is recommended during reconstitution and when wiping the outer surface of the vials and the table after reconstitution.
Incompatibilities: Cymevene should not be mixed with other IV products.
Preparation of Cymevene reconstituted solution: 1. Lyophilized Cymevene should be reconstituted by injecting 10 mL of sterile water for injection into the vial. Do not use bacteriostatic water for injection containing parabens (para-hydroxybenzoates), since these are incompatible with Cymevene sterile powder and may cause precipitation.
2. The vial should be gently swirled in order to ensure complete wetting of the product. Continue swirling until a clear reconstituted solution is obtained. Reconstituted solution should be inspected for particulate matter prior to proceeding with admixture preparation.
3. From a microbiological point of view, the reconstituted solution should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user..
Preparation of Cymevene infusion solution: Based on patient weight the appropriate calculated dose volume should be removed from the Cymevene vial (concentration 50 mg/mL) and added to an acceptable infusion fluid. Normal saline, dextrose 5% in water, Ringer's or lactated Ringer's solution are determined chemically or physically compatible with Cymevene. Infusion concentrations greater than 10 mg/mL are not recommended.
From a microbiological perspective, because Cymevene is reconstituted with non-bacteriostatic sterile water, the infusion solution should be used as soon as possible. If not used immediately in-use storage times and conditions prior to use are the responsibility of the user and should not be longer than 24 hours at 2°C to 8°C.
Disposal of unused/expired medicines: The release of pharmaceuticals in the environment should be minimized.
Medicines should not be disposed of via wastewater and disposal through household waste should be avoided.
The following points should be strictly adhered to regarding the use and disposal of syringes and other medicinal sharps: Needles and syringes should never be reused.
Place all used needles and syringes into a sharps container (puncture-proof disposable container).
Dispose of the full container and of the administration system according to local requirements.