Pregnancy: Crinone is not indicated during pregnancy except for use in early pregnancy as part of an ART regimen (see Dosage & Administration). A large amount of data on pregnant women (more than 1000 exposed outcomes) indicate no association between the maternal use of natural progesterone in early pregnancy and foetal malformations.
Breastfeeding: The use of Crinone is not recommended during lactation.
Fertility: Crinone is indicated for the use of progesterone supplementation of the luteal phase in adults as part of an ART (assisted reproductive technology) procedure (see Indications/Uses).