Discontinue use if depression recurs to serious degree; early manifestations of thrombotic disorders eg, thrombophlebitis, cerebrovascular disorder, pulmonary embolism & retinal thrombosis occur. Conditions influenced by degree of fluid retention eg, epilepsy, migraine, asthma, cardiac dysfunction. History of psychic depression; risk factors for thrombotic disorders. Diabetic patients. May cause local skin reactions due to sorbic acid. Perform gynaecological check-ups prior to initiation & regularly during therapy. Nonfunctional causes should be considered in breakthrough bleeding as in all cases of irregular vag bleeding. Perform adequate diagnostic measures in cases of undiagnosed vag bleeding. May affect ability to drive & use machines. Severe hepatic impairment. Renal dysfunction. Not to be used during pregnancy. Not recommended during lactation. Paed.