Adult NSCLC Monotherapy: 1,000 mg/m
2 IV infusion, repeated once wkly for 3 wk, followed by 1-wk rest period. This 4-wk cycle is then repeated. Combination w/ cisplatin: Regimen 1: 1,250 mg/m
2 given as 30-min IV infusion on days 1 & 8 followed by 1-wk rest period. This 3-wk cycle is then repeated. Regimen 2: 1,000 mg/m
2 given as 30-min IV infusion on days 1, 8 & 15 followed by 1-wk rest period. This 4-wk cycle is then repeated.
Pancreatic adenocarcinoma 1,000 mg/m
2 given as 30-min IV infusion, repeated once wkly for 7 wk followed by 1-wk rest period. Subsequent cycles: Inj once wkly for 3 consecutive wk out of every 4 wk.
Invasive bladder cancer Combination w/ cisplatin: 1,000 mg/m
2 given as 30-min IV infusion on days 1, 8 & 15 followed by 1-wk rest period for 28-day cycle. Cisplatin 70 mg/m
2 to be given on day 2. This 4-week cycle is then repeated.
Breast cancer Paclitaxel 175 mg/m
2 as 3-hr IV infusion on day 1, followed by gemcitabine 1,250 mg/m
2 as 30-min IV infusion on days 1 & 8 of each 21-day cycle.
Ovarian cancer Combination w/ carboplatin: 1,000 mg/m
2 as 30-min IV infusion on days 1 & 8 of each 21-day cycle followed by carboplatin on day 1 to attain target AUC of 4 mg/mL/min.