Cefper Mechanism of Action

Pharmacology: Pharmacodynamics: Cefoperazone is 3^rd generation cephalosporins, which acts against sensitive organisms during the stage of active multiplication by inhibiting biosynthesis of cell wall mucopeptide. Sulbactam does not posses any useful antibacterial activity except Neisseriaceae and Acinetobacter. It is an irreversible inhibitor of most important β-lactamases produced by β-lactam antibiotic resistant organisms. The potential for sulbactam's preventing the destruction of penicillins and cephalosporins by resistant organisms. Combination of cefoperazone and sulbactam demonstrates synergistic activity in a variety of organisms, most markedly the following: Haemophilus influenzae, Bacteroides species, Staphylococcus species, Acinetobacter calcoaceticus, Enterobacter aerogenes, E. coli, Proteus mirabilis, Klebsiella pneumoniae, Morganella morganii, Citrobacter freundii, Enterobacter cloacae, Citrobacter diversus.
Sulbactam/cefoperazone is active against a wide variety organisms: Gram positive: Staphylococcus aureus, penicillinase and non-penicillinase producing strain, S. epidermidis, S. pneumoniae, S. pyrogenes, S. agalactiae, most strain of Beta-hemolytic streptococci.
Gram negative: E. coli, Klebsiella species, Enterobacter species, Citrobacter species, Haemophilus influenzae, Proteus mirabilis, Proteus vulgaris, Morganella morganii.
Pharmacokinetics: Approximately 84% of sulbactam and 25% of cefoperazone is excreted by the kidney. Most of the remaining cefoperazone is excreted via bile. Half-life of sulbactam is 1 hr while that for cefoperazone is 1.7 hrs. Both cefoperazone and sulbactam distribute well into a variety of tissues and fluids including bile, gall bladder, skin appendix, fallopian tubes, ovary, uterus and others.