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History of severe and unexpected reactions to fluoropyrimidine therapy.
Hypersensitivity to capecitabine or to any of the excipients or fluorouracil.
Known complete dihydropyrimidine dehydrogenase (DPD) deficiency.
During pregnancy and lactation.
In patients with severe leukopenia, neutropenia, or thrombocytopenia.
In patients with severe hepatic impairment.
In patients with severe renal impairment (creatinine clearance below 30 ml/min).
Recent or concomitant treatment with brivudine.
If contraindications exist to any of the medicinal products in the combination regimen, that medicinal product should not be used.
