Neutropenia, anaemia; paraesthesia, dysgeusia, headache; increased lacrimation; constipation, dyspepsia; alopecia, nail disorder; arthralgia, pain in extremity; pyrexia, lethargy; chest pain. Monotherapy: Anorexia; diarrhoea, vomiting, nausea, stomatitis, abdominal pain; palmar-plantar erythrodysaesthesia syndrome; fatigue, asthenia. Herpes viral infection, nasopharyngitis, lower resp tract infection; dehydration, decreased wt; insomnia, depression; dizziness; conjunctivitis, eye irritation; thrombophlebitis; dyspnoea, epistaxis, cough, rhinorrhoea; GI haemorrhage, constipation, upper abdominal pain, flatulence, dry mouth; hyperbilirubinemia; LFT abnormalities; rash, erythema, dry skin, pruritus, skin hyperpigmentation & desquamation, macular rash, dermatitis, pigmentation disorder; back pain; peripheral oedema, malaise. Combination therapy: Leucopenia, neutropenic fever, thrombocytopenia; decreased appetite; dysaesthesia, peripheral neuropathy & sensory neuropathy; lower limb oedema, HTN, embolism & thrombosis; sore throat, pharyngeal dysaesthesia; myalgia; weakness, temp intolerance. Herpes zoster, UTI, oral candidiasis, URTI, rhinitis, flu, infection, oral herpes; bone marrow depression, febrile neutropenia; hypersensitivity; hypokalaemia, hyponatraemia, hypomagnesaemia, hypocalcaemia, hyperglycaemia; sleep disorder, anxiety; neurotoxicity, tremor, neuralgia; hypersensitivity reaction, hypoaesthesia; visual disorders, dry eye, eye pain, visual impairment, blurred vision; tinnitus, hypoacusis; atrial fibrillation, cardiac ischaemia/infarction; flushing, hypotension, hypertensive crisis, hot flush, phlebitis; hiccups, pharyngolaryngeal pain, dysphonia; upper GI haemorrhage, mouth ulceration, gastritis, abdominal distension & discomfort, GERD, oral pain, dysaesthesia, paraesthesia & hypoaesthesia, dysphagia, rectal haemorrhage, lower abdominal pain, abnormal hepatic function; hyperhidrosis, erythematous rash, urticaria, night sweats; jaw pain, muscle spasms, trismus, muscular weakness; haematuria, proteinuria, decreased renal CrCl, dysuria; mucosal inflammation, pain, limb pain, chills, flu-like illness, fever, infusion-related reaction & site pain, inj site reaction & pain; contusion.