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Known hypersensitivity to ergot alkaloids, caffeine, or any other components of the formulations (see DESCRIPTION).
Pregnancy and breast-feeding (see Use in PREGNANCY AND LACTATION).
Impaired peripheral circulation, obliterative vascular disease, coronary heart disease, inadequately controlled hypertension, septic conditions, shock.
Severe renal or hepatic impairment.
Temporal arteritis.
Hemiplegic or basilar migraine.
Severe renal or hepatic impairment.
Concomitant treatment with macrolide antibiotics, HIV protease or reverse transcriptase inhibitors, azole antifungals (see INTERACTIONS).
Concomitant treatment with vasoconstrictor agents (including ergot alkaloids, sumatriptan and other 5HT1 receptor agonists) (see INTERACTIONS).
