Caeseva Dosage/Direction for Use

Because of the rapid disintegration of the carbonate salt tablet and its rapid reaction with the hydrochloric acid in the stomach, the dosing of CAESEVA is anticipated to be similar to that of the hydrochloride salt.
CAESEVA should be given three times a day with meals.
Patients Not Taking a Phosphate Binder: The recommended starting dose of CAESEVA is 800 to 1600 mg, which can be administered as one or two CAESEVA 800 mg Tablets, with meals based on serum phosphorus level. Table 1 provides recommended starting doses of CAESEVA for patients not taking a phosphate binder. (See Table 1.)

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Patients Switching from Sevelamer Hydrochloride: For patients switching from sevelamer hydrochloride, sevelamer carbonate should be prescribed on a gram per gram basis. Further titration to the desired phosphate levels may be necessary.
Patients Switching from Calcium Acetate: Table 2 gives recommended starting doses of CAESEVA based on a patient's current calcium acetate dose. (See Table 2.)

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Dose Titration for All Patients Taking CAESEVA: The dose should be increased or decreased by one tablet per meal at two week intervals, as necessary, with the goal of controlling serum phosphorus within the target range of 1.13 mmol/L to 1.78 mmol/L.
Method of administration: Oral use.
Tablets should be swallowed intact and should not be crushed, chewed, or broken into pieces prior to administration. CAESEVA should be taken with food and not on an empty stomach.