Caeseva

Caeseva

sevelamer

Manufacturer:

Duopharma (M)

Distributor:

Duopharma Marketing
Concise Prescribing Info
Contents
Sevelamer carbonate
Indications/Uses
Control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis, or w/ CKD not on dialysis w/ serum P ≥1.78 mmol/L. Multiple therapeutic approach to control renal bone disease development.
Dosage/Direction for Use
Patient not taking phosphate binder Initially 1-2 tab tds based on serum P level. Patient switching from sevelamer HCl Dose based on g/g basis, may further titrate to desired phosphate levels. Patient switching from Ca acetate 1 tab Ca acetate 667 mg equiv to 1 tab Caeseva 800 mg. Dose titration: May be increased/decreased by 1 tab/meal at 2 wk intervals until serum P 1.13-1.78 mmol/L is reached.
Administration
Should be taken with food: Swallow whole, do not crush/chew/break.
Contraindications
Hypersensitivity. Hypophosphataemia; bowel obstruction.
Special Precautions
Not indicated for control of hyperparathyroidism. Multiple therapeutic approach in secondary hyperparathyroidism. Not recommended in CKD adult patients not on dialysis w/ serum P <1.78 mmol/L. Dysphagia; swallowing disorders; severe GI motility disorders including untreated or severe gastroparesis, gastric contents retention, abnormal or irregular bowel motion; active inflammatory bowel disease; major GIT surgery; intestinal obstruction & ileus/subileus; hypo- or hypercalcaemia, metabolic acidosis; hypothyroidism; inflammatory GI disorders. Carefully monitor patients w/ constipation. Closely monitor patients undergoing peritoneal dialysis. Assess serum vit A, D, E & K status, folate levels regularly. Monitor serum Ca & bicarbonate levels during treatment. Not to be taken by patients w/ galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Pregnancy & lactation.
Adverse Reactions
Nausea, vomiting, upper abdominal pain, constipation. Diarrhoea, dyspepsia, flatulence, abdominal pain.
Drug Interactions
Decreased bioavailability of ciprofloxacin. Reduced levels of ciclosporin, mycophenolate mofetil, tacrolimus; closely monitor blood conc during combination treatment & after w/drawal. Closely monitor TSH levels w/ levothyroxine. Possible reduced absorption w/ anti-arrhythmics & anti-seizure medications. Increased phosphate levels w/ PPIs.
MIMS Class
Antidotes & Detoxifying Agents
ATC Classification
V03AE02 - sevelamer ; Belongs to the class of drugs used in the treatment of hyperkalemia and hyperphosphatemia.
Presentation/Packing
Form
Caeseva FC tab 800 mg
Packing/Price
180's
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