Bioflor Special Precautions

This drug is a complement of dietetic rules: rehydration by abundant, salted or sweetened drinks, in order to compensate for the loss of liquid due to the diarrhoea (the average daily ration of water in adult is 2 liters); to feed during the diarrhoea; by excluding certain supply and particularly fruits, green vegetables, spiced dishes, as well as food or frozen drinks; by privileging roasted meats and rice.
IN CASE OF DOUBT, DO NOT HESITATE TO SEEK THE ADVICE OF A DOCTOR OR A PHARMACIST.
The patient must consult immediately a physician in the following cases: in absence of improvement after 2 days of treatment; in case of fever, vomiting; in case of presence of blood or mucus in the stools; in case of intense thirst, dryness of tongue: these signs show the beginning of the dehydration, that means an important loss of liquid due to the diarrhoea. The physician will decide the necessity to prescribe a rehydration which could be administered by oral or IV route.
BIOFLOR 250 mg Capsule and sachet contain living cells. This drug should therefore not be mixed with very hot (over 50°C), iced or alcoholic drinks or food.
BIOFLOR 250 mg Capsule and sachet contains lactose.
If the patient has been told by the doctor that they has an intolerance to some sugars, contact the doctor before taking this medicinal product.
Because of the risk of generalized Saccharomyces boulardii infection, in case of patients with modified immune system (e.g. HIV infection, chemotherapy, irradiation) the drug should be administered only under strict medical control.
It is advisable not to open capsules or sachets in the surroundings of patients with a central venous catheter, to avoid any colonization, especially hand-borne, of the catheter. It is advisable not to open the capsules or sachets in the surroundings of critically ill or immunocompromised patients due to a risk of airborne contamination.
There have been very rare cases of fungaemia reported mostly in patients with central venous catheter, critically ill or immunocompromised patients, most often resulting in pyrexia. In most cases, the outcome has been satisfactory after cessation of treatment by Saccharomyces boulardii, administration of antifungal treatment and removal of the catheter when necessary. However, the outcome was fatal in some critically ill patients (see Contraindications and Adverse Reactions).
Powder for oral suspension: BIOFLOR 250 mg powder for oral suspension in sachet contains fructose.
This medicine contains 471.90 mg fructose in each sachet. In case of frequent use or over a long period of time (e.g. for two weeks or longer), fructose can damage teeth. If the doctor has told the patient (or the child) that they has an intolerance to some sugars or if the patient has been diagnosed with hereditary fructose intolerance (HFI), a rare genetic disorder in which a person cannot break down fructose, talk to the doctor before the patient (or the child) take or receive this medicine.