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Pharmacology: Pharmacodynamics: Betahistine dihydrochloride is a specific histamine agonist with virtually no H2-activity. It appears to act on the precapillary sphincter in the stria vascularis of the inner ear, thus reducing the pressure in the endolymphatic space.
Pharmacokinetics: Betahistine is rapidly and completely absorbed after oral administration of the drug in tablets. It is excreted almost quantitatively in urine as 2-pyridylacetic acid within 24 hours after administration. No unchanged betahistine has been detected.
