Discontinue use if signs of serious reactions or hypersensitivity occur. Not recommended in narrow-angle glaucoma. Metabolic acidosis. Patients w/ pseudoexfoliative or pigmentary glaucoma, compromised corneas (eg, DM or corneal dystrophies); low endothelial cell count; significant renal tubular immaturity or abnormalities. May cause eye irritation due to benzalkonium Cl. Remove contact lens prior to application & wait at least 15 min before reinsertion. Administer at least 5 min apart if >1 topical ophth medicinal product is used. Not recommended to use w/ another carbonic anhydrase inhibitors. May affect ability to drive & use machines. Not recommended in hepatic impairment. Renal impairment. Women of childbearing potential should use effective contraception. Not recommended during pregnancy. Lactation. Not recommended in infants, childn & adolescents <18 yr.
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