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Indications and Dosage
Ophthalmic
Ocular hypertension, Open-angle glaucoma Adult: As 1% susp: Instill 1 drop 2-3 times daily, either alone or as adjunctive therapy w/ a topical β-blocker or prostaglandin analogue.
Elderly: No dosage adjustment necessary. |
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Contraindications
Hypersensitivity to brinzolamide, sulfonamides. Hyperchloraemic acidosis.
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Special Precautions
Patient w/ low endothelial cell count. Hepatic and severe renal (CrCl <30 mL/min) impairment. Pregnancy and lactation.
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Adverse Reactions
Blurred vision, taste abnormality (bitter, sour, or unusual taste), blepharitis, dermatitis, dry eye, foreign body sensation, headache, hyperaemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus, and rhinitis.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anaemia, and other blood dyscrasias. |
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Ophth: C
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Patient Counseling Information
This drug may cause temporary blurred vision or other visual disturbances, if affected do not drive or operate machinery.
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Monitoring Parameters
Monitor intraocular pressure.
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Drug Interactions
Concurrent use w/ oral carbonic anhydrase inhibitors may lead to additive systemic effects. Concurrent use w/ high-dose salicylates may lead to toxicity.
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Action
Description:
Mechanism of Action: Brinzolamide is a carbonic anhydrase inhibitor that decreases secretion of aqueous humour thus reducing intraocular pressure. Pharmacokinetics: Absorption: Absorbed into systemic circulation. Distribution: Brinzolamide and metabolites: Accumulates in RBCs and bind to carbonic anhydrase. Plasma protein binding: Approx 60%. Metabolism: Metabolised to N-desethyl brinzolamide. Excretion: Via urine as unchanged drug and metabolites. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 68844, Brinzolamide. https://pubchem.ncbi.nlm.nih.gov/compound/Brinzolamide. Accessed Feb. 23, 2023. |
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Storage
Store between 4-30°C.
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MIMS Class
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References
Anon. Brinzolamide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 01/10/2014. Azopt Suspension (Alcon Laboratories, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 01/10/2014. Buckingham R (ed). Brinzolamide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 01/10/2014. McEvoy GK, Snow EK, Miller J et al (eds). Brinzolamide (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 01/10/2014.
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