Avoxidil Special Precautions

Patients being considered for minoxidil therapy should have a history and physical examination taken. The physician should determine that the patient has a normal scalp.
There is no evidence that enough minoxidil is absorbed to cause systemic effects, some absorption of minoxidil from the skin does occur and the potential exists for systemic effects such as salt and water retention, generalized and local edema, pericardial effusion, pericarditis, tamponade, tachycardia, angina or potentiation of the orthostatic hypotension produced by guanethidine.
Patients with a history of underlying heart diseases should be made aware that minoxidil may aggravate these conditions. Patients should be observed periodically for any suggestion of systemic effects of minoxidil.
In the event of systemic side effects discontinue administration of the drug. If necessary, fluid retention and edema can be managed with diuretic treatment. Tachycardia and angina can be controlled by administration of β-adrenergic blocking drugs or other sympathetic nervous system suppressants. Patients should discontinue use of Avoxidil and contact their physician in the event of systemic effects or severe dermatologic reactions.
Minoxidil may cause burning and irritation of the eye. In the event of accidental contact with sensitive surfaces (eye, abraded skin, mucous membranes), the area should be bathed with copious amounts of cool tap water.
Accidental ingestion of minoxidil could lead to serious side effects.
The effects of minoxidil in patients with concomitant dermal diseases or in those using topical corticosteroids or other dermatologic preparations are unknown.
Effects on Ability to Drive and Use Machine: This product may cause dizziness or hypotension. If affected, patients should not drive or operate machinery.
Use in Children: Safety and effectiveness in patients below the age of 18 years have not been established.