The most frequently encountered side effect with topical application of minoxidil was mild dermatitis of the scalp.
Infrequently reported side effects included irritant dermatitis (redness, scaling and burning), nonspecific allergic reactions, hives, allergic rhinitis, facial swelling, sensitivity, shortness of breath, headache, neuritis, dizziness, lightheadedness, syncope, vertigo, edema, chest pain, blood pressure changes, palpitations and pulse rate changes.
Rarely reported side effects included allergic contact dermatitis, folliculitis, alopecia (hair loss), unwanted hypertrichosis and seborrhea.
Other than mild dermatological events, a causal relationship between the previously mentioned side effects and the use of minoxidil has not been established.