Augmentin Dosage/Direction for Use

To minimise potential gastrointestinal intolerance, administer at the start of a meal. The absorption of AUGMENTIN is optimised when taken at the start of a meal.
Treatment should not be extended beyond 14 days without review.
Therapy can be started parenterally and continued with an oral preparation.
Tablet: Dosage depends on the age and renal function of the patient and the severity of the infection.
Tablets should be swallowed whole without chewing. If required, tablets may be broken in half and swallowed without chewing.
AUGMENTIN tablets are not recommended in children of 12 years and under.
Adults and Children over 12 years: The usual recommended daily dosage is: Mild - Moderate infections: One AUGMENTIN 625 mg tablet every 12 hours.
Severe infections: One AUGMENTIN 1 g tablet every 12 hours.
Renal Impairment: No adjustment in dose is required in patients with creatinine clearance (CrCl) greater than 30 mL/min. The AUGMENTIN 1 g tablet should only be used in patients with a creatinine clearance (CrCl) rate of more than 30 mL/min. (See Table 4.)

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Hepatic Impairment: Dose with caution; monitor hepatic function at regular intervals.
Oral suspension: Dosage depends on the age, weight and renal function of the patient and the severity of the infection.
Dosages are expressed throughout in terms of amoxicillin/clavulanate content except when doses are stated in terms of an individual component.
AUGMENTIN bottle presentations for suspension may be supplied with a plastic dosing device. For preparation of the suspensions, see Instructions for Use/Handling under Cautions for Usage.
The usual recommended daily dosage is: 25/3.6 mg/kg/day in two divided doses for mild to moderate infections (upper respiratory tract infections e.g. recurrent tonsillitis, lower respiratory infections and skin and soft tissue infections).
45/6.4 mg/kg/day in two divided doses for the treatment of more serious infections (upper respiratory tract infections e.g. otitis media and sinusitis, lower respiratory tract infections e.g. bronchopneumonia and urinary tract infections).
No clinical data are available on doses above 45/6.4 mg/kg/day in children under 2 years.
There are no clinical data for AUGMENTIN suspension 228 mg/5 mL and 457 mg/5 mL to make dosage recommendations for children under 2 months old.
The tables as follows give dosage guidance for children.
Children over 2 years: (see Table 5.)

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Children aged 2 months to under 2 years: (See Table 6.)

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Renal Impairment: No adjustment in dose is required in patients with creatinine clearance greater than 30 mL/min.
AUGMENTIN suspension 228 mg/5 mL and 457 mg/5 mL are not recommended in patients with a creatinine clearance of less than 30 mL/min.
Hepatic Impairment: Dose with caution; monitor hepatic function at regular intervals. There is, as yet, insufficient evidence on which to base a dosage recommendation.
Injection: Dosage for the treatment of infections: Adults and children over 12 years: Usually 1.2 g eight hourly. In more serious infections, increase frequency to six-hourly intervals.
Children 3 months-12 years: Usually 30 mg/kg^*AUGMENTIN eight hourly. In more serious infections, increase frequency to six-hourly intervals.
Children 0-3 months: 30 mg/kg^*AUGMENTIN every 12 hours in premature infants and in full term infants during the perinatal period, increasing to eight hours thereafter.
^*Each 30 mg AUGMENTIN contains 25 mg amoxicillin and 5 mg clavulanate.
Adult dosage for surgical prophylaxis: The usual dose is 1.2 g AUGMENTIN intravenous given at the induction of anaesthesia. Operations where there is a high risk of infection, e.g. colorectal surgery, may require three, and up to four, doses of 1.2 g AUGMENTIN intravenous in a 24-hour period. These doses are usually given at 0, 8, 16 (and 24) hours. This regimen can be continued for several days if the procedure has a significantly increased risk of infection.
Clear clinical signs of infection at operation will require a normal course of intravenous or oral AUGMENTIN therapy post-operatively.
Dosage in renal impairment: Adults: See Table 7.

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Children: Similar reductions in dosage should be made for children.
Dosage in hepatic impairment: Dose with caution; monitor hepatic function at regular intervals.
Each 1.2 g vial of AUGMENTIN contains 1.0 mmol of potassium and 3.1 mmol of sodium (approx.).
Administration: AUGMENTIN intravenous may be administered either by intravenous injection or by intermittent infusion. It is not suitable for intramuscular administration.