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Injection: AUGMENTIN intravenous should not be mixed with blood products, other proteinaceous fluids such as protein hydrolysates or with intravenous lipid emulsions.
If AUGMENTIN is prescribed concurrently with an aminoglycoside, the antibiotics should not be mixed in the syringe, intravenous fluid container or giving set because loss of activity of the aminoglycoside can occur under these conditions.
Instructions for Use/Handling: Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Tablet: Blister pouches contain a desiccant sachet; do not remove or eat. Discard any opened and unused tablets after storing as directed in Storage as follows.
Oral suspension: AUGMENTIN suspension in bottles: For bottles with aluminium screw caps, check the cap ring seal is intact before using. Alternatively, for bottles with a plastic child-resistant cap, check the foil-backed bottle seal is intact before using.
At time of use, the dry powder should be reconstituted to form an oral suspension, as detailed as follows: Invert and shake bottle to loosen powder.
Add volume of water (indicated as follows). Invert and shake well.
Alternatively, fill the bottle with water to just below the mark on bottle label. Invert and shake well, then top up with water to the mark. Invert and shake again.
Allow to stand for 5 minutes to ensure full dispersion.
Shake well before taking each dose. (See Tables 8 and 9).
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Click on icon to see table/diagram/imageA plastic dosing device may be supplied with the pack which can be used to measure the dose accurately.
Discard any unused suspension after 7 days.
Injection: 600 mg vial: To reconstitute dissolve in 10 ml Water for Injections BP. (Final volume 10.5 ml).
1.2 g vial: To reconstitute dissolve in 20 ml Water for Injections BP. (Final volume 20.9 ml).
A transient pink coloration may or may not appear during reconstitution.
Reconstituted solutions are normally colourless or a yellow colour.
Intravenous injection: The stability of AUGMENTIN intravenous solution is concentration dependent, thus AUGMENTIN intravenous should be used immediately upon reconstitution and given by slow intravenous injection over a period of 3-4 minutes. AUGMENTIN intravenous solutions should be used within 20 minutes of reconstitution. AUGMENTIN may be injected directly into a vein or via a drip tube.
Intravenous infusion: Alternatively, AUGMENTIN intravenous may be infused in Water for Injections BP or Sodium Chloride Intravenous Injection BP (0.9% w/v). Add, without delay*, 600 mg reconstituted solution to 50 ml infusion fluid or 1.2 g reconstituted solution to 100 ml infusion fluid (e.g. using a minibag or in-line burette). Infuse over 30-40 minutes and complete within four hours of reconstitution. For other appropriate infusion fluids, see Stability and Compatibility as follows.
*Solutions should be made up to full infusion volume immediately after reconstitution.
Any residual antibiotic solutions should be discarded.
Therapy can be started parenterally and continued with an oral preparation.
Treatment should not be extended beyond 14 days without review.
Stability and Compatibility: Intravenous infusions of AUGMENTIN may be given in a range of different intravenous fluids. Satisfactory antibiotic concentrations are retained at 5°C and at room temperature (25°C) in the recommended volume of the following infusion fluids. If reconstituted and maintained at room temperature, infusions should be completed within the times stated. (See Table 10.)
Click on icon to see table/diagram/imageReconstituted solutions should not be frozen.
AUGMENTIN is less stable in infusions containing glucose, dextran or bicarbonate. Reconstituted solutions of AUGMENTIN should therefore not be added to such infusions but may be injected into the drip tubing over a period of 3-4 minutes.
For storage at 5°C, the reconstituted solution should be added to pre-refrigerated infusion bags which can be stored for up to 8 hours. Thereafter, the infusion should be administered immediately after reaching room temperature. (See Table 11.)
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