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Antacids derived from magnesium, aluminium and calcium can decrease the digestive absorption of diacerein. In case of concomitant use, there should be a minimum time interval of 2 hours between the intake of any of these preparations and ARTRODAR.
No pharmacological interactions have been described with warfarin, phenytoin, indomethacin, salicylic acid, glibenclamide, hydrochlorothiazide and NSAIDs. In addition, no interaction was observed in interaction studies with cimetidine and paracetamol. Intake of diacerein can lead to diarrhoea and hypokalaemia. Caution must be exercised in the concomitant administration of diuretics (high-ceiling loop and thiazides) and/or cardiac glycosides (digitoxin, digoxin), as the risk of arrhythmia is increased.
