Arixtra Adverse Reactions

Adverse reactions are listed below by system organ class and frequency and indication. Frequencies are defined as: very common (≥ 1/10), common (≥ 1/100, <1/10), uncommon (≥ 1/1,000, <1/100), rare (≥ 1/10,000, <1/1,000), very rare (≥ 1/10,000). These adverse reactions should be interpreted within the surgical or medical context of the indications.
Clinical Trial Data: Infections and infestations: Rare: Post-operative wound infections.
Blood and lymphatic system disorders: Common: Anaemia, bleeding (various sites including rare cases of intracranial/ intracerebral and retroperitoneal bleedings), purpura.
Uncommon: Thrombocytopenia, thrombocythaemia, abnormal platelets, coagulation disorder.
Immune system disorders: Rare: Allergic reaction (including very rare reports of angioedema, anaphylactoid/anaphylactic reaction).
Metabolism and nutrition disorders: Rare: Hypokalaemia.
Nervous system disorders: Uncommon: Headache.
Rare: Anxiety, confusion, dizziness, somnolence, vertigo.
Vascular disorders: Rare: Hypotension.
Respiratory, thoracic and mediastinal disorders: Rare: Dyspnoea, coughing.
Gastrointestinal disorders: Uncommon: Nausea, vomiting.
Rare: Abdominal pain, dyspepsia, gastritis, constipation, diarrhoea.
Hepatobiliary disorders: Uncommon: Abnormal liver function tests, hepatic enzymes increased.
Rare: Bilirubinaemia.
Skin and subcutaneous tissue disorders: Uncommon: Rash, pruritus, wound secretion.
General disorders and administration site conditions: Common: Oedema.
Uncommon: Fever.
Rare: Reaction at injection site, chest pain, leg pain, fatigue, flushing, syncope.