Arian Overdosage

Symptoms and Treatment of Overdose: Accidental or intentional acute overdosage of aripiprazole alone was identified in patients with estimated doses up to 1260mg with no fatalities.
The potentially medically important signs and symptoms observed included lethargy, blood pressure increased, somnolence, tachycardia and vomiting. In addition, accidental overdose with aripiprazole alone (up to 210mg) in children have been received with no fatalities. The potentially medically serious signs and symptoms include somnolence and transient loss of consciousness.
Overdose Management: Management of overdose should concentrate on supportive therapy, maintaining an adequate airway, oxygenation and ventilation, and management of symptoms. The possibility of multiple drug involvement should be considered. Therefore cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias. Following any confirmed or suspected overdose with aripiprazole, close medical supervision and monitoring should continue until the patient recovers. Activated charcoal (50 g), administered one hour after aripiprazole, suggesting that charcoal may be effective for overdose management. Although there is no information on the effect of hemodialysis in treating an overdose with aripiprazole, hemodialysis is unlikely to be useful in overdose management since aripiprazole is not eliminated unchanged by the kidneys and is highly bound to plasma proteins.