Discontinue use if NMS or tardive dyskinesia occur. Hyperglycemia & DM. Orthostatic hypotension, CV disease; patients at risk for aspiration pneumonia; suicide. History of seizures or conditions that lower seizure threshold eg, Alzheimer's dementia. Body temp regulation. Avoid heat exposure & dehydration; alcohol. May affect ability to drive & use machines. Not indicated in pregnancy & lactation. Ped <18 yr. Elderly.
Enhanced effect of certain antihypertensives. Increased clearance by CYP3A4 inducers eg, carbamazepine. Inhibited elimination by CYP3A4 inhibitors eg, ketoconazole or CYP2D6 inhibitors eg, quinidine, fluoxetine, paroxetine. Concomitant use w/ alcohol.
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