Aprovasc Dosage/Direction for Use

The usual initial and maintenance dose of Aprovasc is one tablet per day. Aprovasc can be administered with or without food.
Aprovasc should be administered in patients whose blood pressure is not adequately controlled on monotherapy with irbesartan or amlodipine or for continuation of therapy for patients receiving irbesartan and amlodipine as separate tablets. Dose should be determined on a case-by-case basis, based on patient response to therapy with the individual components and the desired antihypertensive response. The maximum recommended dose with Aprovasc is 300 mg/10 mg per day.
Treatment should be adjusted based on blood pressure response.
Pediatric patients: The safety and efficacy of Aprovasc has not been established in this population.
Elderly patients and patients with impaired renal function: In general, no dosage reduction is necessary in elderly patients or patients with impaired renal function (regardless of the degree of impairment).
Patients with impaired hepatic function: As the medicinal product contains amlodipine, Aprovasc should be administered with caution in these patients (see Precautions).
Medicinal product for oral administration.