Analab Overdosage

Capsule: Clinical features: Cold, clammy skin; confusion; convulsion, severe dizziness; severe drowsiness; pinpoint pupils of eyes; slow heartbeat; slow or troubled breathing; unconsciousness; severe weakness.
Treatment: Intensive supportive therapy may be required to correct failure and shock. In addition, the specific antagonist naloxone hydrochloride is used to counteract very rapidly the severe respiratory depression and coma produced by excessive doses of opioid analgesics.
Injection: Symptoms: The cardinal signs of a tramadol overdose are mydriasis or miosis and respiratory depression up to respiratory failure.
Other typical symptoms include clouding of consciousness to the point of coma, generalized epileptic seizures, hypotension, tachycardia, vomiting, cardiovascular collapse.
Treatment: The signs and symptoms of tramadol intoxication can be abolished by administration of an opioid antagonist (e.g., naloxone) which should be administered carefully in repeated small doses, since its duration of action is shorter than that of tramadol, aspiration and emptying stomach. However, naloxone administration for tramadol overdose may increase the risk of seizures.
In addition, intensive care measures (intubation and mechanical ventilation in particular) should be instituted. The use of benzodiazepines should be considered for patients with seizures.
Measures aimed at protecting against the loss of heat as well as volume replacement therapy may also become necessary.
Hemodialysis or hemofiltration alone is not sufficient or suitable due to the slow elimination of tramadol from the serum by these route.