Ampholip Drug Interactions

Nephrotoxic Drugs: Amphotericin B is a potentially nephrotoxic and particularly close monitoring of renal function is required in patients receiving nephrotoxic drugs concomitantly.
Zidovudine: In dogs, exacerbated myelotoxicity and nephrotoxicity were observed when Ampholip was administered concomitantly with zidovudine. If concomitant treatment with zidovudine is required, renal and haematologic function should be closely monitored.
Cyclosporin: Preliminary data suggest that patients receiving Ampholip concomitantly with high dose of cyclosporine experience an increase in serum creatinine. The data also suggest that the increase in serum creatinine is caused by cyclosporin and not by Ampholip.
Flucytosine: The use of flucytosine with Ampholip has not been studied. While the synergy between Amphotericin B and flucytosine has been reported, Amphotericin B may enhance the toxicity of flucytosine by increasing its cellular uptake and impeding its renal excretion.
Conventional Amphotericin B has been reported to interact with antineoplastic agents, corticosteroids and corticotrophin (ACTH), antiarrhythmic agents digitalis glycosides and skeletal muscle relaxants.