Severe systemic &/or deep mycoses in cases where toxicity or renal failure precludes use of conventional amphotericin B in effective doses & where prior systemic antifungal therapy has failed. Disseminated candidiasis & aspergillosis; severely neutropenic patients.
Not intended for common, clinically inapparent fungal diseases diagnosed only by skin tests or serological determinations. Pre-existing renal disease, monitor renal function prior to & at least once wkly during therapy; administer after completion of dialysis in patients undergoing dialysis. Regularly monitor serum K & Mg levels. Not to be diluted w/ saline soln or mix w/ other drugs or electrolytes. Not to be used w/ in-line filter. Concomitant use w/ hepatotoxic drugs. May affect ability to drive & use machines. Pregnancy & lactation.
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