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Overdosage of Aldara Cream 5% w/w in humans is unlikely due to minimal percutaneous absorption. Animal studies reveal a dermal lethal dose of greater than 5000mg/kg. Persistent topical overdosing of Aldara Cream 5% w/w could result in severe local skin reactions. These usually subside within 2 weeks of Aldara Cream 5% w/w discontinuation.
Following accidental ingestion of a single 200mg imiquimod (corresponds to the content of approximately 16 sachets), nausea, emesis, headache and fever can occur. The most clinically serious adverse event reported following multiple oral imiquimod doses of >200mg was hypotension which resolved following oral or intravenous fluid administration.
