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In cases of chronic use or abuse, the loss of potassium can potentiate the effect of cardiac glycosides and influence the action of antiarrhythmics. Loss of potassium can be enhanced in combination with certain diuretics, cortisone or cortisone-like substances (adrenocortical steroids) and liquorice roots.
The absorption of concurrently administered drugs from the gastrointestinal tract into the blood stream can be delayed. A reduction of the insulin dose can be required in insulin-dependent diabetics.
