Acute MI 90-min dose regimen (started w/in 6 hr after symptom onset):
Patient ≥65 kg 15 mg IV bolus immediately followed by 50 mg IV infusion over 1st 30 min, followed by 35 mg IV infusion over 60 min until max: 100 mg,
<65 kg 15 mg IV bolus immediately followed by 0.75 mg/kg IV infusion over 1st 30 min (max: 50 mg), followed by 0.5 mg/kg IV infusion over 60 min up to max: 35 mg.
3-hr dose regimen (started between 6-12 hr after symptom onset):
Patient ≥65 kg 10 mg IV bolus immediately followed by 50 mg IV infusion over 1st hr, followed by 40 mg IV infusion for next 2 hr until max: 100 mg,
<65 kg 10 mg IV bolus immediately followed by up to max: 1.5 mg/kg IV infusion.
Acute massive pulmonary embolism Patient ≥65 kg 10 mg IV bolus over 1-2 min immediately followed by 90 mg IV infusion over 2 hr until total dose: 100 mg,
<65 kg 10 mg IV bolus over 1-2 min immediately followed by up to max: 1.5 mg/kg IV infusion.
Acute ischaemic stroke Total dose: 0.9 mg/kg IV infusion over 60 min w/ 10% of total dose administered initially as early as possible w/in 4.5 hr of symptom onset. Max: 90 mg.
Adjunctive therapy If heparin is required for other indication (eg, DVT prevention), dose not to exceed 10,000 IU daily SC.