Zithromax Caution For Usage

Instructions for Use, Handling and Disposal: Tablets: The tablets should be swallowed whole.
Powder for Oral Suspension: Tap the bottle to loosen the powder. To the 600-mg bottle, add 9 mL of water. Shake well. Shake immediately prior to use.
For children weighing <15 kg, the suspension should be measured as closely as possible.
For children weighing ≥15 kg, the suspension should be administered using an appropriate measuring device.
IV Solution Preparation for IV Administration: Reconstitution: Prepare the initial IV solution for infusion by adding 4.8 mL of sterilized water for injection to the 500-mg vial and shaking the vial until all of the drug is dissolved. Since Zithromax IV is supplied under vacuum, it is recommended that a standard 5-mL (non-automated) syringe be used to ensure that the exact amount of 4.8 mL of sterilized water for injection is dispensed. Each mL of the reconstituted solution contains azithromycin 100 mg.
Chemical and physical in-use stability of the reconstituted product has been demonstrated for 24 hrs below 30°C. When diluted according to the instructions, the diluted solution is chemically and physically stable for 24 hrs at or below 30°C or for 7 days if stored under refrigeration 5°C.
From a microbiological point of view, Zithromax IV should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally be no longer than 24 hrs at 2°-8°C, unless reconstitution and dilution have taken place in controlled and validated aseptic conditions.
Dilute this solution further prior to administration according to the instructions as follows: Dilution: To provide Zithromax over a concentration range of 1-2 mg/mL, transfer 5 mL of the Zithromax 100-mg/mL solution into the appropriate amount of any of the diluents.
For a final infusion solution concentration of 1 or 2 mg/mL, add 500 or 250 mL diluent to the solution, respectively.
The reconstituted solution can be diluted with: Normal saline (0.9% sodium chloride), ½ normal saline (0.45% sodium chloride), 5% dextrose in water, lactated Ringer's solution, 5% dextrose in ½ normal saline (0.45% sodium chloride) with 20 mEq potassium chloride, 5% dextrose in lactated Ringer's solution, 5% dextrose in ¹/₃ normal saline (0.3% sodium chloride), 5% dextrose in ½ normal saline (0.45% sodium chloride), Normosol-M in 5% dextrose, Normosol-R in 5% dextrose.
Parenteral drug products should be inspected visually for particulate matter prior to administration. If particulate matter is evident in reconstituted fluids, the drug solution should be discarded.
Azithromycin Prolonged-Release Granules 2 g: Constitution: Add 60 mL water and replace cap. Shake well.
Patient Instructions: Azithromycin prolonged-release granules 2 g bottles: Keep the container tightly closed. Do not store above 30°C. Use the prepared suspension within 12 hrs. Shake well before use. Drink the entire contents of the bottle.