Widecillin Special Precautions

It is necessary that the patient's history be taken to predict adverse reactions eg, shock symptoms.
Widecillin should not be used in patients suffering from shock symptoms due to previous administration of amoxicillin for infectious mononucleosis.
Widecillin should be given under close clinical observation to: Patients who have a past history of hypersensitivity to penicillins or cephems (cephalosporins and cephamycins).
Patients who themselves, or whose parents or siblings, have a constitution susceptible to allergic reactions eg, bronchial asthma, eruption and urticaria.
Patients with severely impaired renal function. Since a high blood concentration is maintained, Widecillin should be administered at sufficient intervals.
Superinfections, especially in the gastrointestinal tract, have been noted, particularly when large doses were given or therapy was prolonged.