Sulperazon Drug Interactions

Alcohol: A reaction characterized by flushing, sweating, headache and tachycardia has been reported when alcohol was ingested during and as late as the 5th day after cefoperazone administration. A similar reaction has been reported with certain other cephalosporins and patients should be cautioned concerning ingestion of alcoholic beverages in conjunction with administration of Sulperazon. For patients requiring artificial feeding orally or parenterally, solutions containing ethanol should be avoided.
Drug-Laboratory Test Interactions: A false-positive reaction for glucose in the urine may occur with Benedict's or Fehling's solution.
Incompatibilities: Aminoglycosides: Solutions of Sulperazon and aminoglycosides should not be directly mixed, since there is a physical incompatibility between them. If combination therapy with Sulperazon and an aminoglycoside is contemplated (see Combination Therapy under Indications), this can be accomplished by sequential intermittent IV infusion provided that separate secondary IV tubing is used, and that the primary IV tubing is adequately irrigated with an approved diluent between doses. It is also suggested that doses of Sulperazon be administered throughout the day at times as far removed from administration of the aminoglycoside as possible.
Lactated Ringer's Solution: Initial reconstitution with Lactated Ringer's Solution should be avoided since these mixtures have been shown to be incompatible. However, a 2-step dilution process involving initial reconstitution in water for injection will result in a compatible mixture when further diluted with Lactated Ringer's Solution (see Instructions for Use/Handling: Lactated Ringer's Solution under Dosage & Administration).
Lidocaine: Initial reconstitution with 2% lidocaine HCl solution should be avoided since these mixtures were shown to be incompatible. However, a 2-step dilution process involving initial reconstitution in water for injection will result in a compatible mixture when further diluted with 2% lidocaine HCl solution (see Instructions for Use/Handling: Lidocaine under Dosage & Administration).