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Hypersensitivity to ibuprofen. Active and recurrent peptic ulcer or risk of gastrointestinal hemorrhage, ulcerative colitis, serious liver and/or kidney failure.
Owing to a possible crossed allergic reaction with acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen must not be administered in patients with history of allergic reactions to medicines alike eg, asthma, rhinitis, urticaria, nasal polyps and angioedema.
Spedifen is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
