Each capsule contains: Erdosteine 300 mg.
Pharmacology: Erdosteine pharmacologically acts as a bronchial mucus fluidifying agent. Erdosteine is classified under the mucolytic drugs. Erdosteine beside its property of fluidifying bronchial mucus thus facilitating expectorations, shows effects as antagonizing the formation "in loco" of free radicals and as contrasting the action of elastase enzyme. Pharmacological studies show that Erdosteine, as such, does not possess these properties but only after metabolization, transform into active metabolites which have the chemical -SH groups. These metabolites break the -SH groups and bringing about a reduction in the mucus elasticity and viscosity thus facilitating the expectoration.
The chemical -SH groups, distinctive of this activity, are chemically blocked and become free only after metabolization or in alkaline moiety. This property guarantees a good tolerability without bad tastes and without mercaptanic regurgitations and with good gastric tolerability.
SANCOSTEIN is indicated as mucolytic fluidifying agent in acute and chronic airways affections.
1 capsule, 2-3 times a day.
With dosage exceeding the suggested ones (900 mg/day): sweating, vertigo, and flushing have been observed.
In patient hypersensitive to Erdosteine and other compositions.
In patients suffering from hepatic cirrhosis and deficiency of the cystathionine-synthetase enzyme.
Phenylketonuria, due to the presence of aspartame, only for the granulate in suspension.
In patient with severe renal failure (creatinine clearance < 25 mL/min).
The product in granulates (suspension) contains sucrose, keep this into consideration in case of diabetes or low-calorie diets.
Effect on ability to drive and use machines: No effects have been reported.
Use in Pregnancy & Lactation: safety of Erdosteine in pregnancy has not been established and therefore as with all new drugs, its use is not recommended, also during lactation its use is not recommended.
Safety of Erdosteine in pregnancy has not been established and therefore as with all new drugs, its use is not recommended, also during lactation its use is not recommended.
No gastrointestinal nor systemic side effects due to the drugs have been observed. If undesirable effect occurred, it should be informed to the physician.
No harmful interaction have been observed with other medicaments and the drug can be administered together with antibiotics, bronchodilators (theophylline, β2 - mimetics, cough sedatives, etc.).
R05CB15 - erdosteine ; Belongs to the class of mucolytics. Used in the treatment of wet cough.
Sancostein cap 300 mg
2 × 10's (Rp87,000/boks)
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