Oxytetracycline, hydrocortisone.
Each gram contains: Oxytetracycline Hydrochloride equivalent to Oxytetracycline 30 mg, Hydrocortisone 10 mg.
Pharmacology: Oxytetracycline is a potent broad-spectrum antibiotic which is useful topically for prevention or treatment of superficial cutaneous infections due to a variety of pyogenic bacteria, both Gram-positive and Gram-negative.
Hydrocortisone is primarily effective because of its anti-inflammatory, antipruritic, and vasoconstrictive actions. In the treatment of superficial infections of the skin amenable to Oxytetracycline therapy, the anti-inflammatory action of the Hydrocortisone in this ointment will afford prompt symptomatic relief while the Oxytetracycline is acting against the causative organisms.
Where topical therapy with Hydrocortisone is of value, the added presence of Oxytetracycline will serve to prevent or eradicate secondary bacterial complications. Since varying degrees of bacterial infection frequently complicate those skin conditions for which Hydrocortisone topical therapy is indicated, this combined preparation may offer therapeutic advantages over the use of Hydrocortisone alone.
Combination Oxytetracycline and Hydrocortisone is thus useful in the treatment of skin conditions in which antibacterial and anti-inflammatory effects are desired.
In the allergic dermatoses, the inciting allergens in the food or environment should be determined and eliminated; patch test, intradermal tests or other suitable procedures should be employed to determine the allergens.
Cutaneous infections: For steroid-responsive dermatoses with bacterial infections e.g., superficial pyogenic infections, pyoderma pustular dermatitis, and infections associated with minor burns or wounds (under close supervision).
Atopic dermatitis: Including allergic eczema, both disseminated and circumscribed neurodermatitis, pruritus with lichenifications, eczematoid dermatitis, food eczema, and infantile eczema.
Contact dermatitis: Due to plants, drugs, cosmetics, clothing material, and miscellaneous substances.
Only for infected dermatitis or those showing secondary infection. If secondary infections are not already seen, it is recommended to have a culture done before use.
After thorough cleansing of the affected skin areas, a small amount of the ointment should be applied gently. Applications should be made 2 - 4 times daily. When actual infection is present, the ointment may be applied on sterile gauze and, by this means, kept in continuous contact with the affected area. Care should be taken not to discontinue therapy too soon after the initial response has been obtained.
Acute herpes simplex vaccinia, and varicella.
Tuberculosis of the skin.
Fungal diseases of the skin.
Hypersensitivity to any components of SANCORTMYCIN Ointment.
SANCORTMYCIN Ointment is not for ophthalmic use.
If irritation develops, SANCORTMYCIN Ointment should be discontinued and appropriate therapy instituted.
Concomitant use of Oxytetracycline and other antibiotics may result in overgrowth of resistant organisms, particularly Candida and Staphylococci. Constant observation of the patient for this possibility is essential. If new infections due to nonsusceptible bacteria or fungi appear during therapy, appropriate measures should be taken. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.
If extensive areas are treated, or if occlusive technique is used, there will be increased systemic absorption of the corticosteroid; suitable precautions should be taken particularly in children and infants.
Use in pregnancy: Although topical steroids have not been reported to have an adverse effect on human pregnancy, the safety of their use in pregnant women has not absolutely been established. Therefore, drugs of this class should not be used extensively on pregnant patients, in large amounts or for prolonged periods of time.
Pregnancy: Although topical steroids have not been reported to have an adverse effect on human pregnancy, the safety of their use in pregnant women has not absolutely been established. Therefore, drugs of this class should not be used extensively on pregnant patients, in large amounts or for prolonged periods of time.
Oxytetracycline and Hydrocortisone are well tolerated by the epithelial tissues and may be used topically with minimal untoward effects.
Allergic reactions may occur occasionally but are rare.
The following local adverse reactions have been reported with topical corticosteroids, especially under occlusive dressing: Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria.
The use of SANCORTMYCIN Ointment should be discontinued if such reactions occur.
D07CA01 - hydrocortisone and antibiotics ; Belongs to the class of weak (group I) corticosteroids, in combination with antibiotics. Used in the treatment of dermatological diseases.
Sancortmycin oint
10 g x 1's
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