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Carboplatin is contraindicated in patients with the following conditions: Severe myelosuppression; Pre-existing severe renal impairment; dose adjustment may allow use in the presence of mild renal impairment (see DOSAGE & ADMINISTRATION); History of severe allergic reactions to Carboplatin, other platinum-containing compounds or mannitol; Bleeding tumors.
Use in pregnancy: Safe use of Carboplatin in pregnancy has not been established and its use in pregnancy is not recommended. Women of child bearing potential should use adequate contraception.
Use in lactation: It is not known whether Carboplatin is excreted in breastmilk. To avoid possible harmful effects in the infant, breast feeding is not advised during Carboplatin therapy.
