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Emergency treatment of cardiac arrhythmias, Thyrotoxic crisis
Adult: 1 mg via IV inj over 1 minute, may be repeated every 2 minutes until response is achieved. Max: 10 mg in conscious patients or 5 mg in patients under anaesthesia. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).
Oral
Cardiac arrhythmias
Adult: As conventional tab or oral solution: 10-40 mg 3-4 times daily.
Child: As conventional oral solution or tab: 0.25-0.5 mg/kg 3-4 times daily.
Child: As conventional oral solution or tab: 0.25-0.5 mg/kg 3-4 times daily.
Oral
Angina pectoris
Adult: As conventional tab or oral solution: Initially, 40 mg 2-3 times daily, may be increased at weekly intervals according to response. Usual range: 120-240 mg daily. As extended-release cap: 80 mg once daily, may be increased to 160 mg once daily. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).
Oral
Hypertrophic cardiomyopathy
Adult: As conventional tab or oral solution: 10-40 mg 3-4 times daily.
Oral
Essential tremor
Adult: As conventional tab or oral solution: Initially, 40 mg 2-3 times daily, may be increased according to response. Usual range: 120-320 mg daily. As extended-release cap: 80 mg once daily. Dose may be increased to 160 mg daily and, if needed, further increased to 240 mg daily.
Oral
Proliferating infantile haemangioma
Child: ≥5 weeks Hemangeol (4.28 mg/mL oral solution) Patients weighing ≥2 kg: Start treatment between 5 weeks and 5 months of age. Initially, 0.6 mg/kg (0.15 mL/kg) bid for 7 days, then increase to 1.1 mg/kg (0.3 mL/kg) bid for additional 7 days and then increase to maintenance dose of 1.7 mg/kg (0.4 mL/kg) bid for 6 months. Doses are given at least 9 hours apart during or right after feeding or meals. Adjust dose periodically as the child's weight increases. Treatment may be restarted if haemangiomas recur. Treatment recommendations and product availability may vary between countries (refer to specific product guidelines).
Oral
Tetralogy of Fallot
Child: Infants and children As conventional oral solution: For treatment and prophylaxis of cyanotic attacks and for relief of right-ventricular outflow tract obstruction: Up to 1 mg/kg 3-4 times daily. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).
Oral
Anxiety
Adult: As conventional tab or oral solution: For short-term relief of acute situational anxiety: 40 mg daily. For relief of generalised anxiety symptoms: 40 mg bid, may be increased if necessary to 40 mg tid. Dosage or treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Oral
Phaeochromocytoma
Adult: As conventional tab or oral solution: As adjunctive treatment to α-receptor blocker: 60 mg daily for 3 days before the surgery. As adjunctive treatment to α-receptor blocker for inoperable cases: 30 mg daily.
Child: As conventional oral solution or tab: 0.25-0.5 mg/kg 3-4 times daily.
Child: As conventional oral solution or tab: 0.25-0.5 mg/kg 3-4 times daily.
Oral
Thyrotoxicosis
Adult: As adjunctive treatment: As conventional tab or oral solution: 10-40 mg 3-4 times daily. As extended-release cap: 80 mg once daily. Dose may be increased to 160 mg daily.
Child: As conventional oral solution or tab: 0.25-0.5 mg/kg 3-4 times daily. Adjust dose according to response.
Child: As conventional oral solution or tab: 0.25-0.5 mg/kg 3-4 times daily. Adjust dose according to response.
Oral
Prophylaxis of variceal bleeding in portal hypertension
Adult: As conventional tab or oral solution: Initially, 40 mg bid, may be increased to 80 mg bid depending on heart rate response. Max: 160 mg bid.
Oral
Hypertension
Adult: Monotherapy or in combination with other antihypertensive agents (e.g. thiazide diuretics): As conventional tab or oral solution: Initially, 40-80 mg bid, may be increased at weekly intervals according to response. Usual range: 160-320 mg daily. Max: 640 mg daily. As extended-release cap: Initially, 80 mg once daily, or 160 mg once daily. Dose may be increased if necessary until adequate response is achieved. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).
Oral
Post-myocardial infarction
Adult: For long-term prophylaxis after recovery from acute MI: As conventional tab or oral solution: Initiate treatment within 5-21 days of MI. Initially, 40 mg 4 times daily for 2-3 days, followed by 80 mg bid. Alternatively, 180-240 mg daily in divided doses. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).
Oral
Prophylaxis of migraine
Adult: As conventional tab or oral solution: Initially, 40 mg 2-3 times daily, may be increased at weekly intervals according to response. Usual range: 80-160 mg daily. Max: 240 mg daily. As extended-release cap: Initially, 80 mg once daily, may be increased gradually to achieve optimum migraine prophylaxis. Usual range: 160-240 mg once daily.
Child: As conventional oral solution or tab: ≤12 years 10-20 mg 2-3 times daily; >12 years Same as adult dose.
Child: As conventional oral solution or tab: ≤12 years 10-20 mg 2-3 times daily; >12 years Same as adult dose.
