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Pharmacology: Minocycline is a semisynthetic antibiotic Tetracyclines of the first available in 1972. Like other Tetracyclines, it has a broad spectrum of activity. Besides having an antibiotic activity, Minocycline also has chelating agent activity and form a chelate with Ca2+, Mg2+, or Al3+ ions in the intestine.
The main mechanism of its activity on protein synthesis: Minocycline is more lipophytic compare to other Tetracyclines and can penetrate directly through the layer of fat on the bacterial cell wall. Energy dependens on pump activity of the drug transport system, like all Tetracyclines are through the inner membrane cytoplasmin. In bacterial cells, Minocycline inhibits protein synthesis by forming ties with the 30S ribosome. Drugs seem to prevent the entry of aminoacyl tRNA to the acceptor in the mRNA ribosome complex. Prevention is to add amino acids to the growth of peptide chains. Minocycline will inhibit protein synthesis in mammalian cells when used at very high concentrations.
