Tetracycline can enhance methoxyflurane-induced nephrotoxicity. Sodium bicarbonate may inhibit Tetracyclines in the digestive tract by increasing the pH.
Minocycline reduce plasma prothrombin activity by inhibiting the production of Vitamin K in intestinal flora.
Antacids containing divalent and trivalent cations, which form a chelate with Tetracyclines, inhibits oral absorption. Cations are found in foods, especially everyday products, and iron preparations have the same effect.
Activities bacteriostatic Tetracycline can interfere with the activities bacterisid Penicillin.