Neurosantin Special Precautions

Although there is no evidence of rebound seizures with Gabapentin, abrupt withdrawal of anticonvulsants in epileptic patients may precipitate status epilepticus. (See DOSAGE & ADMINISTRATION).
Gabapentin is not generally considered effective in the treatment of absence seizures.
Patients who require concomitant treatment with mor­phine may experience increases in Gabapentin con­centration. Patients should be carefully observed for signs of CNS depression, such as somnolence, and the dose of Gabapentin or morphine should be reduced appropriately. (See INTERACTIONS).
Drug Rash with Eosinophilia and Systemic Symptoms (DRESS): Severe, life-threatening, systemic hypersensitivity reactions such as Drug rash with eosinophilia and systemic symptoms (DRESS) have been reported in patients taking antiepileptic drugs including gaba­pentin.
It is important to note that early manifestations of hypersensitivity, such as fever or lymphadenopathy, may be present even though rash is not evident. If such signs or symptoms are present, the patient should be eva­luated immediately. Gabapentin should be discon­tinued if an alternative etiology for the sign or symptoms cannot be established.
Effect on Ability to Drive and Use Machines: Patients should be advised not to drive a car or operate potentially dangerous machinery until it is known that this medication does not affect their ability to engage in these activities.