Neminos Dosage/Direction for Use

NEMINOS 100 or 200 injection can be given intramuscularly or intravenously (both are identical). The dose of Netilmicin Sulfate is stated in equivalency of the amount of Netilmicin. Weight the body mass prior the treatment to get the appropriate dose. Aminoglycoside doses for patients with obesity are based on clean body mass.
Do not mix physically with other drugs, but give them separately according to the recommended route and dose schedule. Usually given intramuscularly in doses equivalent to Netilmicin 4-6 mg/kg/day as a single dose, alternatively can be given in same dose every 8 or 12 hours. For life-threatening infections, doses up to 7.5 mg/kg/day are given in divided dose every 8 hours. The recommended dose for urinary tract infections is a single dose of 150 mg daily or 3-4 mg/kg/day in divided dose every 12 hours. The same dose can be given by intravenous injection 3-5 minutes. Treatment with Netilmicin is usually given for 7 to 14 days.
The recommended dosage for infants and children is slightly different.
For infants and neonates aged more than 1 week 7.5-9 mg/kg/day in divided dose every 8 hours.
For children 6-7 mg/kg/day in divided dose every 8 hours. Premature infants and neonates aged less than 1 week can be given 6 mg/kg/day in divided dose 3 mg/kg every 12 hours. Alternative administration for neonates aged less than 6 weeks 4-6.5 mg/kg/day in divided dose every 12 hours, in infants and children 5.5-8 mg/kg/day in divided dose every 8 or 12 hours.
It is recommended that administration to all patients should be regulated based on plasma Netilmicin concentration. This is important because factors such as age, kidney damage or dosage can give a tendency towards toxicity or a risk of subtherapeutic concentration.
Dosage for renal impairment: Dosage must be adjusted. If possible the level of Netilmicin in the serum is monitored. When no serum level is present and kidney function is stable, creatinine is the most reliable indicator of the level of kidney damage that is easily provided as a guideline for dose adjustment to increase the interval between usual doses. Because creatinine levels in serum have a high correlation with Netilmicin half-life in serum, this laboratory test can provide guidelines for administration interval adjustment. The interval between administration (in hours) can be estimated by multiplying serum creatinine levels (mg/100 mL) by 8. In patients with serious systemic infection and renal impairment, antibiotics can be given more often with reduced doses. In these patients, measure the level of Netilmicin in the serum.
The recommended method is: 1. After the initial or usual loading dose, the guidelines for determining dose reduction at 8-hour intervals are to divide the recommended dose normally with serum creatinine levels.
2. If the creatinine clearance rate is known, the maintenance dose given every 8 hours is calculated using the following formula: see equation.


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The initial dose or loading is the same as recommended for patients with normal renal function. Worsening kidney function can require a larger dose reduction than mentioned for patients with stable renal impairment.
Hemodialysis: Recommended dose: 2 mg/kg at the end of each dialysis period.
In children, a dose of 2-2.5 mg/kg can be given depending on the severity of the infection.