Moxivar Drug Interactions

Moxifloxacin should be administered at least 4 hours before or 8 hours after antacids that contain aluminum or magnesium, didanosine tablets, sucralfate and agents containing iron or zinc. Transient increase in digoxin concentrations may occur; this is not considered clinically important. Dosage adjustment of moxifloxacin or digoxin is not necessary.
No clinically relevant interaction was seen between glibenclamide and moxifloxacin.
Concomitant use of drugs that induce bradycardia or hypokalemia or drugs which induce QT prolongation (neuroleptic, certain anti-infective agents [some antimalarials, azole antimycotics, macrolides], certain antihistaminic [terfenadine, astemizole], cisapride) should be considered carefully. Antiarrhythmic drugs class IA (such as quinidine and procainamide) and III (such as amiodarone and sotalol) are contraindicated. No interactions have occurred following concomitant administration of moxifloxacin with: warfarin, ranitidine, probenecid, oral contraceptives or theophylline. Cases of increased anticoagulant activity have been reported in patients receiving anticoagulants concurrently with antibiotics, including moxifloxacin. After intravenous drug administration, charcoal only slightly reduces systemic exposure to moxifloxacin in cases of overdosage.