Rheumatoid Arthritis and Ankylosing Spondylitis: 15 mg daily. According to the therapeutic response, the dose may be reduced to 7.5 mg daily.
Osteoarthritis: 7.5 mg daily. If necessary, the dose may be increased to 15 mg daily.
In patients with increased risks of adverse reactions, start treatment at the dose of 7.5 mg daily.
In dialysis patients with severe renal failure, the dose should not exceed 7.5 mg daily.
As the potential for adverse reactions increases with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used.
Adolescents: The maximum daily dose is 15 mg.
In general, usage should be restricted to ≥15 years (see Contraindications).
The total daily dose of tablets should be taken as a single dose and should be swallowed with water or other fluid in conjunction with food.